"I don't know what will happen, but this is not like we're getting divorced. This is a separation and I think that takes a lot of courage," Cox told TV Week. "That's for sure the biggest thing I've ever done. Whatever is supposed to happen will be the best thing for us."
The two, who have a 6-year-old daughter, Coco, announced their separation last month after 11 years of marriage. Arquette, 39, recently told Howard Stern that the pair separated because they were not having sex, but Cox downplayed his comments, calling him a "kook."
"Sometimes you just realize 'Wow, we actually have grown apart,'" Cox said. "[David]'s a kook. It's not shocking and Howard Stern — he loves him and I'm a fan of Howard Stern. I don't know that I would call him right now, but ... David is an entertainer and I'm sure the people who listen to the radio are entertained by his stories."
Cox, 46, added that Friends pal Jennifer Aniston has been extremely helpful during this time. "It's funny, a lot of really close friends are kind of going through this right now or like Jennifer [who] has gone through it," she said. "I don't know what's going on in the planets or what, but things are being shaken up and I don't know what's going to happen, but, yeah, Jennifer has been amazing for sure."
As far as dating other people, Cox said she's in no rush.
"I am not doing anything. No dating," she said. "I hate to go out, so, I don't know how that would work. I'm a homebody."