Alex O'Loughlin, Jim Parsons Alex O'Loughlin, Jim Parsons

CBS is kicking off its premiere week with a slightly tweaked Monday-night comedy block —newcomer Mike & Molly replaces The Big Bang Theory, which is moving to Thursdays.

Check out our day-by-day guide to all the networks' fall schedules

How I Met Your Mother will lead off the night, Monday, Sept. 20 at 8/7c, followed by Rules of Engagement and Two and a Half Men. Mike and Molly takes over the 9:30/8:30c spot, just before the premiere of the Hawaii Five-0 reboot at 10/9c.

On Tuesday, Sept. 21, NCIS returns for its eighth season at 8/7c, followed by the two-hour season premiere of NCIS: Los Angeles at 9/8c.

New drama The Defenders premieres Wednesday, Sept. 22 at 10/9c after Criminal Minds at 9/8c.

The Big Bang Theory moves to its new slot on Thursday, Sept. 23 at 8/7c, followed by new comedy $#*! My Dad Says, CSI and The Mentalist.

Friday, Sept. 24, Medium starts out the night at 8/7c, followed by CSI:NY and new police drama Blue Bloods.

Prior to premiere week, Survivor will roll out its 21st edition in Nicaragua on Sept. 15 at 8/7c. Meanwhile, The Good Wife and CSI: Miami will begin new seasons the week of Sept. 27.

Check out the full schedule below:

Wednesday, Sept. 15
8/7c Survivor: Nicaragua

Monday, Sept. 20
8/7c How I Met Your Mother
8:30/7:30c Rules of Engagement
9/8c Two and a Half Men 
9:30/8:30c Mike & Molly (new series)
10/9c Hawaii Five-0 (new series)

Tuesday, Sept. 21
8/7c NCIS
9/8c NCIS: Los Angeles

Wednesday, Sept. 22
9/8c Criminal Minds
10/9c The Defenders (new series)

Thursday, Sept. 23
8/7c The Big Bang Theory
8:30/7:30c $#*! My Dad Says (new series)
9/8c CSI: Crime Scene
10/9c The Mentalist

Friday, Sept. 24
8/7c Medium  
9/8c CSI: NY
10/9c Blue Bloods (new series)

Saturday, Sept. 25
8/7c Crimetime Saturday
9/8c Crimetime Saturday          
10/9c 48 Hours Mystery

Sunday, Sept. 26
7:30/6:30c 60 Minutes
8:30/7:30c The Amazing Race
10/9c Undercover Boss

Tuesday, Sept. 28       
10/9c The Good Wife

Sunday, Oct. 3
8/7c The Amazing Race (regular timeslot)
9/8c Undercover Boss (regular timeslot)
10/9c CSI: Miami