Anyone who sits on the Iron Throne automatically has a huge target on their back. Add to that the fact that Cersei is one of the most hated figures in Westeros, just murdered a bunch of people and has no actual claim to the throne, and you can bet she probably isn't long for this world.
While not included in Game of Thrones, Cersei's death was actually prophesied in the books, where Maggy the Frog told her that after her three children died, the "valonqar" (High Valyrian for little brother) would choke her to death. Will Jaime have to put down his sister just like he did the Mad King? Many fans are betting on it.
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