Made her stage debut in 1978, appearing in Sam Shepard's Pulitzer Prize-winning play Buried Child
Was in the Portland Stage Company with Sarah Jessica Parker, and lived in the same apartment house
Taught drama at Vassar College summer theater in the mid-1980s, and later at the New York Stage and Film Company
Husband Randle Mell played a homeless man opposite her in the 1991 movie Grand Canyon
Has worked twice with director John Sayles, on 1987's Matewan, her first major film role, and 1992's Passion Fish, for which she garnered an Oscar nomination
Like George Clooney, she appeared on the short-lived CBS sitcom titled E/R before landing a role on the famous drama ER (as Noah Wyle's mother)
Has played both a First Lady (in Independence Day) and a President (in Battlestar Galactica)