Child stars are known for capturing the hearts of audiences, but few of them do so into adulthood. Yet this winning actress continues to charm decades after making a splash as a 7-year-old alien-loving cutie in E.T. the Extra-Terrestrial. Unfortunately, while Barrymore inherited the talents of her famous ancestors Lionel, Ethel and John, she also inherited their addictive personalities. While starring as a sweetie pie in a series of '80s films, the adolescent was leading a troubled off-screen life. By the end of the decade, she landed in rehab and her career was in jeopardy. After cleaning up, she reinvented herself on screen as a bad girl (Poison Ivy, The Amy Fisher Story) before finally settling on a sweet, effervescent yet clearly grown-up persona in a string of '90s comedies (The Wedding Singer, Home Fries and Never Been Kissed, the first of many vehicles she produced for herself). In 2000 she added butt-kicking to her résumé as one of three comely detectives in the blockbuster Charlie's Angels, which she also produced, catapulting her to the top of the Hollywood A-list. Barrymore stayed busy in the '00s, starring in a number of successful films, including 50 First Dates, Fever Pitch and He's Just Not That Into You. She made her directorial debut with the quirky 2009 sports drama Whip It. And in 2010, she won raves and a Golden Globe for her convincing portrayal of reclusive socialite Little Edie Beale in HBO's Emmy-winning film Grey Gardens, about two eccentric relatives of Jackie Kennedy-Onassis. Off screen, Barrymore has had a high-profile love life, which includes a short-lived marriage to comedian Tom Green, a five-year relationship with Strokes' drummer Fabrizio Moretti, and an on-again, off-again romance with actor Justin Long.
- At age 7, was the youngest person ever to host Saturday Night Live.
- Posed as Marilyn Monroe on the cover of John Kennedy Jr.'s magazine, George, in honor of Bill Clinton's 50th birthday.
- Called a 23-year-old girl who wanted to be on MTV's I Want a Famous Face and convinced her not to have cosmetic surgery to look like her.
- Received a quilt as a birthday gift from her godfather, Steven Spielberg, with the note "Cover yourself up." Also enclosed was a copy of the January 1995 issue of Playboy magazine for which she posed nude. Her pictures were modified by Spielberg's art department so that she was shown fully clothed.
- Received a star on the Hollywood Walk of Fame on February 3, 2004.
- 2005, People's Choice Awards — Favorite On Screen Match Up: Winner
- 2009, Emmy — Outstanding Lead Actress in a Miniseries or a Movie: Nominee
- 2010, Golden Globe — Best Performance by an Actress in a Miniseries or Motion Picture Made for Television: Winner
- 2000, Emmy — Outstanding Animated Program (for Programming More Than One Hour): Nominee
- 1983, BAFTA Film Awards — Outstanding Newcomer to Leading Film Roles: Nominee
- 2009, Screen Actors Guild Awards — Outstanding Performance by a Female Actor in a Television Movie or Miniseries: Winner
- 1993, Golden Globe — Best Performance by an Actress in a Miniseries or Motion Picture Made for Television: Nominee
- 1985, Golden Globe — Best Performance by an Actress in a Supporting Role in a Motion Picture: Nominee
- 2008, People's Choice Awards — Favorite Leading Lady: Winner
- Ethel Barrymore — Great-aunt
- Jaid Barrymore — Mother
- John Blyth Barrymore — Half Brother
- Jessica Barrymore — Half Sister
- Lionel Barrymore — Great-uncle
- Diana Barrymore — Aunt
- Fabrizio Moretti — Ex-significant Other
- Dolores Costello — Grandmother
- Tom Green — Ex-husband
- Jeremy Thomas — Ex-husband
- John Drew Barrymore — Father
- Blyth Dolores Barrymore — Half Sister
- John Barrymore — Grandfather
- Olive Barrymore Kopelman — Daughter
- Leland Hayward III — Ex-fiancé
- Justin Long — Ex-significant Other
- Frances Bean Cobain — Godchild
- Jamie Walters — Ex-fiancé
- Frankie Barrymore Kopelman — Daughter
- Will Kopelman — Husband
- Birth Name: Drew Blythe Barrymore
- Birth Place: Los Angeles, California, United States
- Birthday: February 22, 1975, Pisces
- Profession: Actor, Producer, Director