Detroit (1-0) at San Francisco (1-0). The 49ers held off Detroit 25-19 last season as Alex Smith threw a go-ahead fourth-down TD pass with 1:51 remaining. The postgame handshake turned into a minor scuffle between coaches Jim Harbaugh and Jim Schwartz after Harbaugh's exuberant approach at midfield. San Francisco RB Frank Gore ran for 141 yards in the victory.

Detroit Lions at
San Francisco 49ers, Sep 16, 2012: TV Listings

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