Premieres: Tuesday, Sept. 2, 8 pm/ET
Who's on it: A whole bunch of shiny, happy newcomers including Shenae Grimes and Tristan Wilds as adoptive siblings; series vets Lori Loughlin and Rob Estes play their thoroughly modern parents.

What it's about: It's a reboot of the classic '90s Fox series, in which a Midwestern family relocates to Beverly Hills. Just to shake things up, this time one of the kids is adopted and African-American. Look for appearances by original cast members Jennie Garth, Shannen Doherty and Joe E. Tata.

Why it's an editors' pick: Nostalgia aside, the creators of Freaks and Geeks remaking 90210 intrigues us.

Premieres: Midseason
Who's on it: Megan Mullally, Alicia Silverstone, Arrested Development's Alia Shawkat

What it's about: Silverstone plays a 32-year-old mom who is charged with caring for her teenage daughter (Shawkat) and her middle-aged mother (Mullally). Based on the British novel and TV movie of the same name.

Premieres: Friday, Oct. 17, 8 pm/ET
Who's on it: Philip Winchester, Sean Bean and Sam Neill, making a rare television appearance

What it's about: NBC has released few details about this adventure series currently filming in the U.K. and South Africa. But it's based on the classic novel about a castaway (Winchester) who spends eight years on a desert island. The series will also depict flashback scenes of his life before his shipwreck, including clashes with his father (Bean) and the counsel of a family friend (Neill).

Premieres: Wednesday, Sept. 10, 9:30 pm/ET
Who's on it: Jerry O'Connell, Niecy Nash

What it's about: O'Connell plays a cocksure womanizer who manages a boutique hotel in New York City. Nash is a brash HR boss who tries to keep everyone in line, both up front and behind the scenes.

Premieres: January 2009
Who's on it: Eliza Dushku, Olivia Williams, Tahmoh Penikett

What it's about: "Who do you want me to be?" is the creepy tagline for this Joss Whedon creation. Echo (Dushku) is an "active," a blank canvas upon which clients assign identities, which are then wiped clean when the engagement is over. Echo lives with other actives in a lab run by the mysterious, madam-like Adelle (Williams). Things go awry when Echo starts to remember her life before it was erased as FBI Agent Paul Ballard (Penikett) closes in on the Dollhouse's illegal operation.

Premieres: Sunday, Sept. 21, 9 pm/ET
Who's on it: Laurie Metcalf, Judge Reinhold, Jeff Hephner

What it's about: Metcalf plays the matriarch of a family of loan sharks. Hephner (The O.C.) is the ethical son who aches to take the biz legit. Reinhold doesn't stray far from his Beverly Hills Cop roots, playing a detective.

Premieres: Thursday, Oct. 9, 10 pm/ET
Who's on it: Rufus Sewell, Marley Shelton

What it's about: Jacob Hood (Sewell) is a special scientific advisor to the FBI who lends his particular skills to criminal investigations. "This is a science fact show, not a science fiction show," says executive producer Ethan Reiff (who also wrote Showtime's Sleeper Cell). Jerry Bruckheimer is also involved, which is a good sign.

Premieres: Friday, Oct. 3, 9 pm/ET
Who's on it: Elizabeth Reaser (Ava/Rebecca from Grey's Anatomy)

What it's about: A psychic tells Bella Bloom (Reaser) she has one year to get married, or else she never will. The catch: Her true love is someone she has already dated. Despite the insane, age-of-Google premise, it's cute. Reaser does a great job handling the show's breezy dialogue, and she plays Bella with such approachable exuberance that you will forget her sad turn on Grey's.

Why it's an editors' pick: Despite its apparent limitations (what happens in Season 2?), its thoroughly modern rom-com premise will have you asking which of your exes might be the one who got away.

Premieres: Tuesday, Sept. 9, 9 pm/ET
Who's on it: Anna Torv, Joshua Jackson, John Noble

What it's about: An FBI agent (Torv) enlists an institutionalized scientist (Noble) and his con-artist son (Jackson) to help solve the mystery of a plane full of people killed by a mysterious necrotizing skin condition. The deadly flight appears to be part of "the pattern," a larger, disturbing nightmare scenario.

Why it's an editors' pick: Joshua Jackson is the wild card in this very serious drama; he'll keep it light and entertaining.

Premieres: Wednesday, Sept. 24, 8:30 pm/ET
Who's on it: Jay Mohr, Paula Marshall

What it's about: The recently divorced Gary (Mohr) tolerates his shrewish ex (Marshall) as they struggle to raise their two kids together and he attempts to find love again. Oh, it's a sitcom.

Premieres: Thursday, Sept. 11, 8 pm/ET
Who's on it: Masochists. Brooke Burns and Mark Thompson co-host.

What it's about: Often referred to as "human Tetris," contestants have mere seconds to bend their bodies to fit through oddly shaped holes in a wall that is rushing at them, ready to drag them into a pool of water. (See YouTube for international versions of the show.)

Why it's an editors' pick: Because apparently our appetite for watching others be humiliated is larger than we thought.

Premieres: Sunday, Sept. 21, 7:00pm/ET
Who's on it: Host is still TBD. Produced by Craig Piligian (Dirty Jobs)

What it's about: This hour-long reality series chronicles the lives of people performing such dangerous jobs as war photographers, oil-well cappers, Phyllis Diller's bikini waxer and minesweepers. (OK, one of those was a joke.)

Premieres: Thursday, Oct. 9, 8:30 pm/ET
Who's on it: Molly Shannon, Selma Blair

What it's about: It's a remake of a broadly comic Australian series (check YouTube) about a strange mother-daughter relationship that develops when Kim (Blair) leaves her husband after six weeks of marriage to move back in with her mom, Kath (Shannon). "Part of the comedy comes from our age difference," says Blair of the fact that Shannon is only 8 years her senior.

Premieres: Midseason
Who's on it: Ian McShane (Deadwood), Australian actor Christopher Egan

What it's about: It's a retelling of the David-and-Goliath story that takes place in a modern-day, although fictional monarchy. David (Egan) is a soldier who, by rescuing the crown prince during wartime, finds his fate intertwined with that of the complicated king (McShane) and his daughter, the princess.

Premieres: Wednesday, Sept. 24, 8 pm/ET
Who's on it: Justin Breuning, Deanna Russo, Sydney Tamiia Poitier, Bruce Davison

What it's about: After the success of a new TV movie that aired in February, NBC is remaking the classic '80s action series about a former military man (Breuning) and his team of experts (including Russo, Poitier, and Davison) who work with an artificial-intelligence-enabled car (voiced by Val Kilmer). The producers have hinted that David Hasselhoff, the star of the original series, may cameo.

Premieres: Thursday, Oct. 9, 10 pm/ET
Who's on it: Jason O'Mara, Harvey Keitel, Michael Imperioli

What it's about: Based on a BBC series, Mars finds New York city police detective Sam Tyler (O'Mara) mysteriously transported back to 1973 in the wake of a car accident. There, Sam's sense of political correctness clashes with the gruff ways of his precinct boss (Keitel) and fellow detectives (including Imperioli).

Premieres: Tuesday, Sept. 23, 9 pm/ET
Who's on it: Simon Baker

What it's about: Patrick Jane (Baker) is a former fake TV psychic who now uses his heightened observation skills to work as a private investigator. If you threw Baker's performances in The Devil Wears Prada and on The Guardian and Smith and USA Networks' Psych into a blender, you'd end up with this smoothie. As cop shows go, it seems sharper than most. Baker is charming, and the show has a tart sense of humor.

Premieres: Monday, Oct. 13, 10 pm/ET
Who's on it: Christian Slater, Saffron Burrows, Alfre Woodard

What it's about: Slater plays Henry, a mild-mannered suburban dad, and Edward, a mysterious international spy. The catch: They share a body, and Henry is starting to become aware of the presence of his very different alter ego. Woodard plays Edward's complicated boss at the spy factory, and Burrows plays Henry's intuitive therapist, who is starting to piece together Edward/Henry's complicated identity.

Why it's an editors' pick: We're excited to watch Christian Slater's dual performances. Plus, Alfre Woodard may finally have landed a juicy part!

Premieres: Tuesday, Sept. 23, 8 pm/ET
Who's on it: J.D. Roth, who cut his teeth as a game-show host at age 19 (with Fun House), oversees the proceedings. Beauty and the Geek's Ashton Kutcher and Jason Goldberg are among the other executive producers.

What it's about: Roth knocks on the doors of pre-screened families, then proceeds to erect a game-show set on their front lawn. Family members are then tested on trivia questions about themselves, and given the chance to win hundreds of thousands of dollars and amazing prizes.

Premieres: Tuesday, Sept. 9, 9 pm/ET
Who's on it: Joanna Garcia, Anne Archer

What it's about: Megan (Garcia), a young writer with dreams of reporting on the rich and famous, moves to Palm Beach and ends up tutoring Hilton-like twins. Archer costars as the girls' imperious grandma, who recognizes that the morally centered Megan could impart more than higher SAT scores to her rambunctious granddaughters.

Premieres: Wednesday, Oct. 22, 9 pm/ET
Who's on it: Elle magazine's Anne Slowey, Joe Zee

What it's about: Think The Devil Wears Prada as a reality show. Eleven fashion-assistant wannabes suck up to Slowey and Zee through a series of challenges set in the world of magazine publishing. The winner gets a job at Elle, an apartment in New York City, and a clothing allowance from H&M. Tyra Banks is among the show's executive producers.

Premieres: Midseason
Who's on it: Bob Saget

What it's about: Saget plays a family man whose household is shaken up by the arrival of new neighbors, including a bombshell daughter who makes Saget think bad things.

Premieres: Sunday, Sept. 7, 9 pm/ET
Who's on it: Anna Paquin, Stephen Moyer (The Starter Wife)

What it's about: In an unspecified future, the invention of synthetic blood makes it possible for vampires (including Moyer's Bill Compton) to walk among us. Paquin plays Sookie Stackhouse, a telepathic, small-town waitress in rural Louisiana. Creator Alan Ball (Six Feet Under), who adapted the novels of Charlaine Harris, promises that Blood will avoid vampire clichés. "One of the things I love about Charlaine's books is the way she treats the supernatural world so matter-of-factly," he says. "We want to keep the supernatural rooted in nature, so that it's just more nature than we're used to in everyday life."

Why it's an editors' pick: Its impressive pedigree: Ball + Paquin + HBO + vampire stories = appointment TV.

Premieres: Sunday, Sept. 21, 8 pm/ET
Who's on it: Jaime Murray, Kristopher Polaha, Robert Baker and Autumn Reeser

What it's about: The Valentines play matchmakers for oblivious soulmates, all the while trying to hide their secret — they're a family of Greek gods.

Premieres: Monday, Sept. 22, 9:30 pm/ET
Who's on it: Kyle Bornheimer

What it's about: Sam (Bornheimer) tries to impress his future in-laws — with disastrous results. It's like Meet the Parents — almost exactly like that, in fact — although it's actually based on a British series called Worst Week of My Life. The pilot is very funny, mostly owing to Bornheimer's excellent comic timing. But how enjoyable will it be to watch Sam demoralize himself on a weekly basis?