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Season finale. Refusing to collaborate with Dr. Zinberg on blood-transfusion research, an increasingly paranoid Thackery pushes himself to the limit, and beyond, in an effort to solve the riddle and beat his rival. Cornelia and Edwards arrive at a crossroads; Barrow trades one creditor for another; Lucy requests Bertie's help.
A late-night crime sheds unfavorable light on The Knick, forcing Robertson to come up with hush money. Lucy goes to extremes to get drugs for a desperate Thackery, whose plea for an advance from a seller of patent medicines falls on deaf ears. Gallinger despairs as Eleanor's behavior becomes more erratic; Cornelia and Edwards proffer different solutions to a shared dilemma.
Already on edge due to a citywide run on cocaine, Thackery worries that Dr. Levi Zinberg, a Jewish surgeon and inventor, will steal his spotlight at the next New York Surgical Society presentation. Bertie continues courting Lucy. Cornelia, Speight and Bertie go to court in an attempt to keep Typhoid Mary Mallon quarantined. Gallinger tries to get Eleanor to move past her grief.
The stabbing of a cop by a black man stirs up racial tension on the street and in the Knick, forcing Thackery and Edwards to take action. Everett returns to work and a changed OR; Barrow fears for Junia's safety; Cornelia is impressed with Edwards' ingenuity; Lucy is escorted home.
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