It won't be the first time the two have worked together. They both starred in Scary Movie 5, which will be released in April.
In her Anger Management episode, which is also scheduled to air in April, Lohan develops a romantic relationship with Sheen's character after becoming his therapy patient.
Lohan and Sheen are also close in real life. Sheen reportedly gave the troubled starlet $100,000 last year to help her pay off her taxes.