Question: I'm so excited! John Stamos is returning to ER next season as a series regular!

Answer: Now are you ready for the bad news?! There are rumblings that a (SPOILER ALERT) major character will be leaving early next season to make room in the budget for Stamos' sizable paycheck. The leading candidates are Kovac or Weaver, one of whom may end up taking the fall for hiring Clemente. But at this point, that's pure speculation. The only thing I'm (90 percent) sure of is that John Leguizamo is history. (And no, his is not the big death I've been referring to.)