Jimmy Martino (John Stamos) definitely has a way with words on Fox's new comedy Grandfathered.

Before his life gets upended when he learns he has a son (Josh Peck) and a granddaughter, the longtime bachelor disarmed the ladies with his choice pick-up lines and smooth delivery. But Jimmy ain't got nothing on Stamos himself.

Fall TV: Grandfathered and 34 other must-see new shows

Check out the exclusive video below to see the granddaddy — no pun intended — of all pick-up lines (and some of the worst).

Grandfathered premieres Tuesday, Sept. 29 at 8/7c on Fox.