Annie Potts, Justin Kirk Annie Potts, Justin Kirk

Ever wonder why Animal Practice's Dr. George Coleman (Justin Kirk) is so good with animals, but so terrible with humans? Wonder no more.

In this exclusive sneak peek from Wednesday's episode (8/7c on NBC), George gets a surprise visit from his outspoken mother Virginia (Annie Potts) and her cat named ... "Cat." Despite their obvious estrangement, Virginia wastes no time bringing out the claws — and we're not talking about those belonging to her feline friend.

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Case in point: "Who wants to date someone who spends half their life with his finger up a dog's keester?" she says  "Speaking of, are you seeing anybody?"

Check out our exclusive video to see how George reacts to his mother's arrival and to hear the rest of Virginia's biting remarks:

The episode, aptly entitled "Who's Afraid of Virginia Coleman," airs Wednesday at 8/7c on NBC.