Spotlight became the first Best Picture winner since 1952's The Greatest Show on Earth and the sixth overall to win only one other award, which was original screenplay. This marked the first time since the preferential ballot was adopted for Best Picture six years ago that the Producers Guild Award, which went to the Oscars' adapted screenplay winner The Big Short, mismatched.
Best dressed stars at the Oscars
The night's biggest winner was Mad Max: Fury Road, which took home six below-the-line awards: costume design, production design and makeup and hairstyling, film editing, sound editing and sound mixing.
After four previous acting nominations and one for producing, DiCaprio won Best Actor for The Revenant. He is the eighth performer to get his first win on his fifth nomination.
Worst dressed stars at the Oscars
The Revenant picked up two other history-making wins. Alejandro G. Inarritu is now the third person, after John Ford and Joseph L. Mankiewicz, and the first in 65 years to win back-to-back directing Oscars. Spotlight's win means this is the 24th time and third in the last four years that picture and director have split. The Revenant's Emmanuel Lubezki became the first person to receive three straight Oscars in cinematography. He's the eighth to win three in the category and is now one behind the record four, held by Leon Shamroy and Joseph Ruttenberg.
Brie Larson (Room) won Best Actress to complete her awards sweep. Her and DiCaprio's wins are the 24th and 25th times a performance swept the Globe, Critics' Choice, Screen Actors Guild Award, BAFTA and Oscar.
The supporting awards went to The Danish Girl's Alicia Vikander and Bridge of Spies' Mark Rylance. At 27, Vikander is now the 10th youngest winner in the supporting actress category. A three-time Tony winner, Rylance upset Sylvester Stallone and is the second person to win an Oscar in a Steven Spielberg film after Daniel Day-Lewis.
Legendary composer Ennio Morricone, 87, finally won his first Oscar, for The Hateful Eight's score, after six nominations and an honorary Oscar.
Sam Smith's "Writing's on the Wall," from Spectre, shocked Lady Gaga and Diane Warren's "'Til It Happens to You" in original song. It's the second Bond song to win after "Skyfall."
Other winners include Inside Out for animated feature and Ex Machina, which pulled off a major upset in visual effects. It is the second non-Best Picture nominee to beat a field of Best Picture nominees in the category since Tora! Tora! Tora! beat Patton 45 years ago.
See the full list of winners below.
Picture: Spotlight (Michael Sugar, Steve Golin, Nicole Rocklin and Blye Pagon Faust, producers)
Director: Alejandro G. Inarritu, The Revenant
Lead Actor: Leonardo DiCaprio, The Revenant
Lead Actress: Brie Larson, Room
Supporting Actor: Mark Rylance, Bridge of Spies
Supporting Actress: Alicia Vikander, The Danish Girl
Original Screenplay: Tom McCarthy and Josh Singer, Spotlight
Adapted Screenplay: Charles Randolph and Adam McKay, The Big Short
Animated Feature: Inside Out
Foreign Language Film: Son of Saul (Hungary)
Documentary Feature: Amy
Cinematography: Emmanuel Lubezki, The Revenant
Costume Design: Jenny Beavan, Mad Max: Fury Road
Documentary Short Subject: A Girl in the River: The Price of Forgiveness
Film Editing: Margaret Sixel, Mad Max: Fury Road
Makeup and Hairstyling: Lesley Vanderwalt, Elka Wardega and Damian Martin, Mad Max: Fury Road
Production Design: Colin Gibson (production design); Lisa Thompson (set decoration), Mad Max: Fury Road
Animated Short Film: Bear Story
Live Action Short Film: Stutterer
Sound Editing: Mark Mangini and David White, Mad Max: Fury Road
Sound Mixing: Chris Jenkins, Gregg Rudloff and Ben Osmo, Mad Max: Fury Road
Visual Effects: Andrew Whitehurst, Paul Norris, Mark Ardington and Sara Bennett, Ex Machina