Ellen had no idea her husband, the president, had died and been replaced by a lookalike. After she found out the truth, she wanted to leave Washington. However, she's reinvigorated as First Lady by Dave's optimism and his wish to improve the nation.

Abbey, a feisty and intelligent Harvard-educated physician and mother of three, hid the president's advancing MS by secretly injecting him to keep his condition in check. She gave up her medical license for the duration of her husband's presidency when her actions were discovered when the president collapsed.

Tess, a surly widow to a former president, makes life hell for her Secret Service agent (Nicolas Cage). Of course, underneath it all, she really loved the guy and asked that his assignment be extended.

The (sort of) First Lady we loved to hate! Sherry is manipulative, deceptive and a real threat to her husband's presidency. Palmer divorced her, but her treachery continued until her death.

Abigail Adams (Laura Linney) John Adams Behind every great man is a great woman. Abigail Adams was brilliant and wise, hardworking and quite often a single parent while her husband was in Philadelphia and abroad. She was her husband's greatest advisor and strongest supporter and became our nation's second First Lady.

Marsha was a power-hungry First Lady to Jack Nicholson's President James Dale whose ambition was rewarded when she was unceremoniously crushed to death by a chandelier when aliens attack the White House.

Marilyn was injured -- and subsequently died -- from massive injuries during an alien attack on her way back from Los Angeles; (McDonnell also appears in our Memorable Presidents gallery as President Roslin from Battlestar Galactica.)

Modeled after Watergate whistleblower Martha Mitchell, Logan's character became disgusted with her husband's actions as president and plotted to end his career. Instead, her mental-health issues lead to being committed to a mental hospital.