Emotions run wild in the mind of a young girl who is uprooted from her peaceful life in the Midwest and forced to move to San Francisco. Joy, Fear, Anger, Disgust and Sadness each have their own ideas about how she should handle her new surroundings. Riley's guiding emotions— Joy, Fear, Anger, Disgust and Sadness—live in Headquarters, the control centre inside Riley's mind, where they help advise her through everyday life and tries to keep things positive, but the emotions conflict on how best to navigate a new city, house and school.
Beekeeper Eva uncovers an ancient fresco while rescuing a hive. Austen, a visiting archeologist, thinks it is key to his research, so he persuades Eva to help him on his quest across Malta.