- Appeared in a 1973 Smokey the Bear public-service announcement.
- Cold-called casting director Joyce Selznick in 1973 and got a reading for a film that turned out to be The Laughing Policeman; she got the part.
- Was set to star in 1975's The Stepford Wives, but was replaced by Paula Prentiss after two weeks of shooting.
- Had the title role in the 1975 TV-adventure Wonder Woman until director Jack Arnold insisted on handing the part to Lynda Carter.
- Voiced Insp. Maggie Sawyer in the WB's Superman: The Animated Series and the 2002 video game Superman: Shadow of Apokolips.
- For the 2007 25th anniversary re-release of Blade Runner: Final Cut, her head was digitally transposed onto that of a stunt performer who had shot the scenes in the original.
- Thirty years after the release of Blade Runner, she teamed with producer-director Tamela D'Amico to shoot a scene of her replicant character Zhora doing an exotic dance with a snake. The scene had originally been choreographed and rehearsed for the 1982 sci-fi film, but was never shot.
- An animal activist, she supports Last Chance for Animals.
- 1984, Emmy — Outstanding Lead Actress in a Comedy Series: Nominee
- 1984, Golden Globe — Best Performance by an Actress in a Television Series - Musical or Comedy: Winner
- 2006, Emmy — Outstanding Guest Actress in a Drama Series: Nominee
- 2005, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Virginia Caskey — Mother
- Joseph A. Caskey — Father
- Naomi Kobrin — Daughter
- Daniel Kobrin — Son
- Adele Hessler — Sister
- Kennard C. Kobrin — Ex-husband
- Ridley Scott — Ex-significant Other
- Attended Syracuse University, Syracuse, NY
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- Birth Name: Joanne Virginia Caskey
- Birth Place: Camden, NJ
- Birthday: August 2, 1945, Leo
- Profession: Actor, Voice artist
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