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Now: Zoe Saldana
She got her start on an episode of Law & Order in 1999, but soon landed in features such as Center Stage, Britney Spears' Crossroads and Drumline. She is probably best known for her small role as pirate Anamaria in Pirates of the Caribbean: The Curse of the Black Pearl and her part as an airport employee in The Terminal.
Then: Nichelle Nichols
Post-Star Trek, Nichols has volunteered for NASA and has also appeared in animated series Futurama and The Simpsons. Most recently, she guested in a Season 2 arc of Heroes as Nana Dawson, the matriarch of a New Orleans family who cares for her orphaned granddaughter and great-nephew, both of whom have abilities.