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Booth (David Boreanaz) and Brennan (Emily Deschanel), Bones
Having Booth and Brennan do the deed didn't outright ruin the show, but it just took so long for it to happen. By the time they finally consummated the relationship — and had a kid, no less! — we'd kind of moved on. And we didn't even get to see the magic moment that was six years in the making!