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Santana Lopez, Glee
Long before Gleeks knew what a set of pipes Naya Rivera had, it was Santana's acid tongue that got her noticed. Back in Season 1, the Lima Heights Adjacent resident served not only as a tough sidekick to the meek Quinn, but also a Sue Sylvester-in-training. Santana's coming out — "the only straight I am is straight-up b----," she so proudly proclaimed — has since softened her, but her best jabs at the rest of the glee club — particularly Rachel the dwarf, "Finnocence," and "Trouty Mouth" — will always hold a special place in our hearts.