21 of 26
Meredith and Derek (Ellen Pompeo and Patrick Dempsey), Grey's Anatomy
Mer and Der's road to happiness hasn't been easy. First, she (unknowingly) slept with her new boss, his estranged wife popped back into town and started working at Seattle Grace, and then there was the laundry list of miscommunication issues between them. But then again, maybe it's all in line with a duo so unconventional they got married via a Post-It.