Must-Watch Finales: 31 Super Season-Enders

Grey's Anatomy (May 20, ABC)

Executive producer Shonda Rhimes says fans should "brace themselves" for the two-hour finale. "None of our characters are going to be the same," she adds, in particular mentioning Derek, Meredith and Cristina. Actress-singer Mandy Moore guest-stars as Bailey's patient; Ryan Devlin plays her husband.