Moved to Chicago after college and studied at the Second City Training Center and ImprovOlympics
Frequently collaborates with fellow Second City alum Rachel Dratch; teamed with Dratch for a sketch-comedy show Dratch & Fey in Chicago and NY
Became first female head writer of Saturday Night Live in 1999 and became Weekend Update co-anchor with Jimmy Fallon in 2000
In 2004, Amy Poehler took over as Update co-anchor upon Fallon's departure from SNL
Named one of Entertainment Weekly's Entertainers of the Year in 2001 and one of People magazine's 50 Most Beautiful People of 2003
Impersonated then-vice presidential nominee Sarah Palin in recurring guest turns on Saturday Night Live, earning an Emmy for her on-target portrayal of the politician
Released her autobiography, Bossypants, in 2011
Her 2016 Emmy for Outstanding Guest Actress in a Comedy Series was shared with Poehler (for when the two hosted a 2015 episode of SNL together) marked the first time an acting Emmy had been shared
Appeared in a series of commercials for American Express