Two Secret Service agents track down mysterious objects at the behest of a warehouse caretaker who oversees a top-secret facility in South Dakota that houses strange and power relics collected by the U.S. government in this sci-fi comedy-drama.
In the series finale, the team learn that Warehouse 13 will be moving to a new location country and are asked by Mrs. Frederic to contribute to a time capsule, which they do after reliving the moment that defined their relationship to the top-secret storage facility for supernatural artifacts.
Valda escapes from Paracelsus's alternate universe, and then hatches an evil plan to move the Warehouse to China in order to profit from all of its power, and tries to use Claudia's comatose sister as a puppet Caretaker.
Pete, Myka and Artie try to help Pete's ex-girlfriend Kelly Hernandez when her grandmother gets trapped inside a telenovela, but things go awry when they all end up as characters in the soap opera. Meanwhile, a strange accident at a university leads Claudia and Steve to discover an artifact that literally duplicates its users.
Pete and Myka travel to Washington, D.C., to investigate drowning incidents that have occurred on dry land. While there, they cross paths with a pair of Secret Service agents who cause them to evaluate their relationship. Meanwhile, Artie uses an artifact to take Claudia back into his memories of an old case involving her sister.
Season 5 begins with Claudia facing off against Paracelsus, but he manages to escape back in time to the 9th century. While Pete and Myka try to track down the villainous alchemist, their friends discover that history has been changed for the worst and the Warehouse is now a house of horrors.