A female firefighter must decide if she should donate part of her lung to her captain, who mistreats her. Meanwhile, Andy's uncle shows up with a stab wound and asks Andy not to report the incident because he fears it will violate his parole.
A billionaire's wife needs a liver transplant, but a setback causes her to miss out on a new liver, so her husband buys one on the black market. Meanwhile, a friend from Andy's past unexpectedly shows up.
A car-crash victim (Mandy Patinkin) dying from a progressive neurodegenerative disease requests to be taken off of life support so his organs can be donated. Meanwhile, David cares for a foster parent with pulmonary hypertension who refuses to be admitted to the hospital.
An 8-year-old boy is crushed by a ride at a fair, and Lisa becomes very attached to him in the hospital since she witnessed the accident. Meanwhile, Andy and David attempt to obtain a ventricular-assist device for a patient whose heart is failing.
A team of Pittsburgh surgeons perform organ transplants and deal with the emotionally complex lives of the recipients. In the opener, a pregnant woman suffers a heart attack and is told she must undergo a heart transplant in order to save her life and the life of her unborn child.