In Columbus, Sgt. Nate Smith helps recovering addicts get treatment while zeroing in on a dealer who is mixing heroin with lethal Fentanyl. In Mexico, Don Miguel finds himself trapped in the drug trade, while Mario, a young activist, looks for his missing brother. Back in Atlanta, Skyler signs himself up for long-term treatment but struggles to follow through. Series finale.
Don Miguel celebrates a birthday as rivals close in. In Columbus, Special Agent James tracks down the missing suspect who may be the key to breaking open his case. Meanwhile in Akron, Laura and Dan locate their fugitive son and convince him to turn himself in and begin rehab.
A drug trafficker explains how heroin is transported to the U.S. In Columbus, Special Agent James executes a significant drug bust and begins to track the local heroin supply back to its cartel sources. In Atlanta, John hits the street to feed his habit before an impending court date.
Don Miguel struggles to keep control of local poppy fields in Guerrero, Mexico. Back in Columbus, Ohio, Det. Mark Edwards orchestrates a traffic stop to close in on a local heroin dealers. In Atlanta, Skyler moves back home with his parents to get clean.