In the series premiere, Alicia Florrick (Julianna Margulies), a politician's wife, resumes her career as a defense attorney after her husband is jailed for corruption. Her first case is the retrial of a woman accused of murdering her spouse. The first trial ended with the jury deadlocked. Alicia is told by her new boss to stick with the firm's original strategy, but she decides not to do so when more evidence surfaces.
A stripper claims she was raped at a prominent businessman's bachelor party, and Alicia represents her in a civil trial after the state's attorney refuses to pursue criminal charges. At home, Alicia's kids receive compromising photos of their dad with another woman.
Alicia returns to her old upscale neighborhood to defend a former friend's teen son, who is accused of murdering a security guard at a friend's house. The 18-year-old man admits he was at the home but claims he's innocent of the crime. Cary is assigned to help Alicia with the case, even though he has never tried one in court.
Alicia discovers evidence that a juror may have been bribed with $35,000 in a class-action lawsuit against a major pharmaceutical company. Alicia's client was paralyzed after taking one of the company's drugs. Meanwhile, Peter's lawyer tries to get Alicia to help in her husband's defense and attempts to bribe her with gifts.
Alicia defends the widows of three train engineers who are blamed by their company for a deadly crash. She has 72 hours to prove that the train company is at fault or the women will lose their husbands' pensions. Meanwhile, Kalinda digs into the background of a potential partner in the firm who is seeing Diane, and Peter suspects that Alicia is being unfaithful. Martha Plimpton guest stars.
Alicia works on an appeal for a death-row inmate jailed six years ago for killing an off-duty police officer during the robbery of a grocery store. Peter has vital information about the case and Alicia agrees to a conjugal visit with him to obtain it. But things don't go quite as Peter planned.
Alicia serves as co-counsel to a handsome storefront lawyer (Chris Bowers) who is defending an Orthodox Jewish couple being sued in a slip-and-fall case. Alicia is assigned because one of the defendants is a law partner's daughter. The victim claims she was badly injured when she tripped on a wire outside of the couple's house, but Alicia believes the incident may be a scam. Meanwhile, Will and Diane make a round of layoffs at the firm.
Alicia defends a scientist accused of arson after the lab the woman works in is torched. It's soon learned that the scientist is the target of a hate group. Meanwhile, Alicia is asked to testify on her husband's behalf at his bail hearing, but she is uncertain if she wants him to return home; and Zach becomes determined to uncover the identity of the person who is leaving damaging photos and DVDs at the Florrick's front door.
Alicia represents the firm's senior partner after he is arrested for DUI and assaulting a police officer, and she must deal with the murky office politics that come with the case. Meanwhile, Chelsea Handler interviews Peter's mistress, who is promoting a tell-all book about her affair with Peter.
Alicia investigates a judge's questionable motives after he overturns a simple plea bargain she arranged and sentences her juvenile client to nine months in detention. Her investigation reveals the judge has a history of unusual sentences and may be a racist. Meanwhile, Diane is offered a judgeship and considers leaving the firm.
Alicia represents the state attorney general's wife in her divorce case and becomes a pawn in the negotiations. She also learns more about Peter's legal troubles. Meanwhile, a sarcastic TV commentator goes on trial for slander after he accuses a woman of murdering her missing daughter.
A star high-school quarterback dies from an overdose of painkillers, and Alicia defends the family physician who is charged with murder for prescribing the medication. The doctor claims he is innocent, and Alicia attempts to uncover the truth. Meanwhile, Jackie suffers a stroke, and Childs asks Kalinda to work for him to help undermine Peter's appeal.
Alicia defends a wealthy man in civil court who is accused of murdering his wife. He was found not guilty in his criminal trial but even Alicia believes he committed the crime. Meanwhile, Peter's appeal begins, and Diane buys a gun for protection when a drug dealer threatens to kill her.
Alicia represents a man accused of murdering a babysitter who worked for his family and with whom he had a secret personal relationship. Meanwhile, Childs forces Kalinda to testify at Peter's appeal hearing, and she shocks the judge with her testimony.
Alicia defends a man accused of murdering a financial adviser who lost the man's life savings in a Ponzi scheme. At home, Peter adjusts to house arrest and begins his comeback strategy with his legal team after his son shows him incriminating photos that were left at their door weeks earlier.
Alicia and Will defend an attorney arrested for murdering a witness against a drug dealer he represents; and Alicia discovers that someone is slandering her on the Internet with postings that claim she is sleeping with Will to advance her career.
An emergency courtroom is set up in a hospital, where Alicia and Will attempt to force an insurance company to pay for lifesaving in-utero surgery. At the apartment, Alicia gives Peter a proper homecoming.
Alicia and Will defend a college student accused of killing her roommate while under the influence of a sleep aid. The two also deal with the mounting sexual tension between them. Meanwhile, Diane continues her flirtatious relationship with a conservative ballistics expert.
Peter's electronic monitor sounds off when he chases after Alicia, and their kids try to figure out a way to cover for him so he won't be arrested and sent back to prison. Meanwhile, Alicia defends an illegal immigrant who is threatened with deportation after 27 years in the U.S., and Will serves as a judge in a mock trial designed to train aspiring lawyers.
Alicia and Cary work overtime to keep their jobs when they learn that Will and Diane will soon announce their decision about who will be the firm's junior associate. Meanwhile, Alicia represents the wife of a rock star in a divorce case that takes an unusual turn when the singer is involved in a serious accident that puts him on life support.
Alicia once again defends accused wife killer Colin Sweeney (Dylan Baker), when he's found handcuffed to a dead woman. Sweeney claims self-defense. Meanwhile, Eli Gold tries to get the charges against Peter dropped.
The first season concludes with Alicia contemplating whether to support Peter in his new political campaign or pursue a relationship with Will. Meanwhile, an undercover detective who was gathering information on dirty cops is killed, and his widow believes he was set up, so she sues the police department.