Dr. Shaun Murphy and Dr. Morgan Reznik grapple with a terminal cancer patient who is determined to live the last few months of his life without inhibition. Meanwhile, Dr. Reznik must confront her relationship with her mother when she comes in for a third opinion from Dr. Glassman; and Shaun and Carly's relationship reaches a new level of intimacy.
Dr. Audrey Lim, Dr. Shaun Murphy and Dr. Morgan Reznick treat a 25-year-old runner suffering from severe swelling; but when things take a turn for the worse, Dr. Murphy enlists the help of Dr. Carly Lever. Meanwhile, Dr. Alex Park, Dr. Claire Browne and Dr. Neil Melendez treat two 16-year-old cancer patients who are dating; and Dr. Murphy and Dr. Lever work toward intimacy.
Dr. Shaun Murphy visits his father on his deathbed and the reunion reveals unexpected results. Meanwhile, Dr. Neil Melendez, Dr. Alex Park, Dr. Morgan Reznick and Dr. Claire Browne treat an injured star NFL player with severe spinal damage; and Claire addresses her mental health.
Shaun is ready for the next step in his relationship with Carly. However, he continues to struggle as they grow closer and more intimate, and is dealt some troubling news about a deeply personal issue. Meanwhile, a young patient must decide on a treatment that could save her life or possibly destroy her marriage.
Carly's attempts at increasing her intimacy with Shaun are becoming more of a frustration than either of them expected. Meanwhile, Lim and Melendez struggle in their relationship as they work to separate their work from their personal life.
Dr. Shaun Murphy's unique ability to relate to a patient isolated by an immune deficiency yields an unexpected result. Meanwhile, Dr. Claire Browne, Dr. Morgan Reznick and Dr. Marcus Andrews treat a 12-year-old patient who is about to become blind, and tension builds between Dr. Neil Melendez and Dr. Audrey Lim.
While performing his first solo surgery, Dr. Shaun Murphy alienates a nurse, which puts his residency in jeopardy. Also, Dr. Neil Melendez disagrees with Dr. Audrey Lim on a risky surgery, and Dr. Claire Brown spirals into self-destructive behaviors, causing negative ramifications in the workplace.
Dr. Shaun Murphy has been assigned his first surgery by Dr. Audrey Lim. However, Dr. Marcus Andrews questions whether he is really ready. Meanwhile as Dr. Claire Brown continues to avoid her complicated emotions about her mother, she and Dr. Morgan Reznick have a patient whose diagnosis has them doubting his story.
A conspiracy theorist questions Dr. Neil Melendez about his liver damage; and Dr. Claire Brown treats a woman whose inability to feel pain is threatening both her marriage and her life. Meanwhile, Dr. Shaun Murphy and Dr. Aaron Glassman each face crises in their romantic relationships.
Dr. Claire Brown faces complications at home and work as she prepares to lead her first surgery. Meanwhile, a sports fishing accident challenges the rest of the staff as they look to treat the fisherman's injuries without damaging his prize catch.
Dr. Marcus Andrews vows to help a good Samaritan who was injured while stopping a sexual assault, while Dr. Audrey Lim faces a difficult decision when a young patient's parents suspect that Dr. Neil Melendez made a mistake. Meanwhile, Dr. Shaun Murphy fields advice following his disastrous date with Dr. Carly Lever; and Dr. Claire Browne gets a surprise visit from her mother.
In the Season 3 premiere, Dr. Shaun Murphy proposes a radical surgery to save a woman's life after what he believes was a disastrous first date with Carly. Meanwhile, after the new chief of surgery, Dr. Audrey Lim, announces that the residents can lead surgeries, Dr. Morgan Reznick and Dr. Alex Park compete for the chance to operate on an elderly patient who has been diagnosed with cancer.