Dr. Shaun Murphy questions his decision to give the new residents autonomy when one of his intern's misdiagnosis of a patient has dire consequences. Meanwhile, Dr. Claire Browne, Dr. Alex Park and Dr. Jordan Allen treat a patient with a ruptured cyst affecting key functions of her brain. And elsewhere, Dr. Morgan Reznick and Park bond over failed relationships.
Dr. Morgan Reznik and Dr. Shaun Murphy's pregnant patient with twins is having pain and they are forced to grapple with a decision no one wants to make. Meanwhile, Shaun asks Lea to move back in despite her reservations.
With several candidates vying for residency at St. Bonaventure, Chief of Surgery Dr. Audrey Lim tasks Dr. Shaun Murphy, Dr. Claire Browne and Dr. Alex Park with mentoring the top first-year resident contenders. As their mentees shadow them for the day, Shaun and Park meet with Andrews to discuss a difficult surgery scheduled for a minor. Later, Shaun inadvertently insults Lea while discussing the pros and cons of the controversial surgery.
Dr. Shaun Murphy and Dr. Marcus Andrews determine that their patient has been infected with COVID-19. As they struggle to understand and get ahead of a constantly evolving virus, Shaun has a hard time balancing his fears and concerns about potentially jeopardizing Lea's health and wanting to be with the woman he loves. Meanwhile, Claire looks for a way to grieve Melendez's death through her patients.
Dr. Shaun Murphy treats a patient with an illness that is not only unpredictable in nature, but also unlike anything he or the team at San Jose St. Bonaventure has ever seen before. As safety protocols and quarantines increase due to the global pandemic, Lea and Shaun's new relationship will become tested; and Dr. Alex Park gets ready to move back to Phoenix, Arizona, to be closer to his family.