Dr. Shaun Murphy questions the need for an elective surgery that will allow his young patient to smile for the first time. Meanwhile, Dr. Claire Brown and Dr. Morgan Reznick discover that their patient lied about her identity.
Dr. Shaun Murphy's teenage patient has been confined to her home her entire life due to a rare heart condition. Despite her condition, she has cultivated a large group of friends online and hopes that the surgical team can find a way to give her the life she has always dreamed of having. Meanwhile, a young patient's perfectly matched organ donor is causing a moral dilemma for the parents and the patient.
Dr. Shaun Murphy is surprised to learn that his young cancer patient identifies as a girl while being biologically male. Shaun must quickly learn to understand his patient, her medical needs and how to work with her family, who all feel they know what is best for her.
Dr. Shaun Murphy suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Meanwhile, Dr. Neil Melendez's personal life could be affecting his work and, ultimately, his patients lives.
The twins suffer complications from their surgery forcing the team at San Jose Boneventure Hospital to make a life-changing decision. Meanwhile, Dr. Shaun Murphy returns to the hospital after his trip with Lea and decides he needs a more permanent change and gives Dr. Aaron Glassman his two weeks' notice.
Dr. Marcus Andrews enlists Dr. Neil Melendez on a very sensitive kidney transplant between a pair of twins whose lives intersect in more ways than one. Meanwhile, overwhelmed by Dr. Aaron Glassman's attempts to have him meet with a therapist and the demands at work, Dr. Shaun Murphy decides to take an impromptu trip with his friend Lea and leave everything behind.
Members of the hospital's surgical team are initially impressed with a charming young doctor, but his true character puts one of them in an awkward position at work. Meanwhile, Glassman feels Shaun needs a little more support with his personal life and suggests he meet with a therapist. However, Shaun is determined to show him that he can do it on his own
As part of St. Bonaventure hospital's international humanitarian program, the team takes on the case of a young boy from the Congo who has severe congenital heart anomalies. Dr. Neil Melendez has doubts about the safety of the procedure, while Dr. Shaun Murphy works out the best course of action. Meanwhile, Murphy's latest encounter with his neighbor Lea has him confused.
During a robbery at the grocery mart Dr. Shaun Murphy is shopping at, his communication limitations puts lives at risk. Meanwhile, after Shaun's traumatic day, Dr. Aaron Glassman worries that he isn't doing enough to help Shaun.
Shaun and Claire devise an experimental procedure capable of saving a young groom's leg and life, but the patient's loved ones must learn to work together. Meanwhile, Jared struggles to connect with a patient whose scars may prove too deep to overcome.
Shaun meets a young patient who resembles his brother who's deceased, and he can't understand why this boy's parents hid the truth from him about his own health. Meanwhile, the team can't figure out what's triggering their patients' allergic reactions.
Neil and the team have to wade through legal waters when a decision about an unborn child is needed. Meanwhile, Shaun struggles to adjust to his new environment at home and makes a huge step forward with his colleagues.
A patient isn't honest with his doctors, and this may cost him his chance at life-saving surgery. Meanwhile, Claire must learn how to communicate with Shaun as they race back to the hospital with a donated organ.
Shaun's first day at St. Bonaventure Hospital is complicated by his attention to detail. Meanwhile, Claire learns a valuable lesson about honesty when confronted with a difficult diagnosis for her patient.
Shaun relocates from a quiet country life to join a prestigious hospital, but he faces skepticism from the hospital's board and staff in the series premiere of this drama about a talented young surgeon with savant syndrome.