Dean travels five years into the future and is attacked by zombies who were turned into monsters after being infected with a demonic virus. Sam and Dean soon learn that the virus is Satan's tool to destroy mankind.
Citizens of a small town are being killed by dead icons, such as Abraham Lincoln, and by infamous objects, like James Dean's car. Later, two teens claim a friend was kidnapped by Paris Hilton (appearing as herself).
Sam and Dean investigate a series of murders that echo fairy tales and urban legends. Their probe leads them to an 11-year-old boy who's able to make everything he believes come true. Castiel thinks the lad is a threat and wants him eliminated.
Bobby plays a high-stakes poker game with a witch and bets 25 years of his life for a chance to be free of his wheelchair, but he loses. As he begins to rapidly age, Dean attempts to save him, but he also ages into an old man.
Sam and Dean are thrown into an alternate universe where they become characters in various TV shows, including a medical series, a Japanese game show, a forensics procedural and a sitcom. Castiel warns them that if they don't find a way out soon, they will become trapped inside forever.
Sam, Dean and Castiel search for Lucifer (Mark Pellegrino) in order to send him back to Hell. They are aided in their dangerous quest by fellow hunters Bobby, Ellen and Jo. Bobby: Jim Beaver. Ellen: Samantha Ferris. Jo: Alona Tal.
A teenage nerd (Colton James) conjures up a spell to swap bodies with Sam. After the switch, the boy investigates a case with an unwitting Dean and enjoys the perks of being good-looking and older. Meanwhile, Sam is stuck in the kid's body and deals with intrusive parents and high school.
Sam and Dean go back in time to 1978 and are reunited with their parents. Their mission is to prevent their mom and dad from being murdered by Anna, who is ordered by the angels to stop Sam from being conceived so Lucifer won't be able to use him as a vessel in the future.
Sam and Dean are rescued from demons by townspeople preparing for the apocalypse. They meet a pastor's daughter who claims to be a prophet, but she turns local citizens against each other, and the brothers must decide whether she should be killed.
Bobby trades his soul for the location of Death so Sam and Dean will have a better chance of stopping the Apocalypse. Meanwhile, the brothers confront Pestilence, who unleashes a deadly virus upon them; Dean attends a meeting with Death.
Photo Credits: Diyah Pera/CW; Michael Courtney/CW; Sergei Bachlakov/CW; CW; Jack Rowand/CW; Bettina Strauss/CW; Colin Bentley/CW; Netflix; Pop TV; Robert Viglasky, Hartswood Films; Fred Hayes/Disney+, Fox, PopTV; Bettina Strauss/Netflix; Nicole Rivelli/Amazon, Netflix, Frank Masi/Apple, Disney, Jasper Savage/Hulu