New York City's unflappable, charismatic deputy mayor makes his clueless boss look good in this sharply written, well-played sitcom. Parkinson's disease forced Michael J. Fox to leave the show in 2000, the year he won the Emmy as Outstanding Lead Actor in a Comedy Series. He was replaced by Charlie Sheen, who stayed with the show until its end in 2002.

Sleeping with the Enemy; She's Gotta Habit

First Aired: November 6, 2001

Politics make strange bedfellows of Charlie and the opposition's comely strategist (Denise Richards), who may have her eye on Caitlin. Meanwhile, Paul tangles with the Mayor's cagey adviser (Queen Latifah). Claire: Farrah Fawcett. Sister Agnes: Katherine Joosten. Caitlin: Heather Locklear. Paul: Alan Ruck.