A new patient who has a link to Dean Munsch's past checks into the institute with the intention of winning her back; a jealous Brock further questions his relationship with Chanel; and Chamberlain and Zayday try to learn the origins of the Green Meanie killer.
Dean Munsch's efforts to grab positive press for the hospital leads to her pitching a risky surgery to Dr. Holt, whose hand is acting stranger than ever. Meanwhile, Chanel #3 forces Cassidy to take a psych test to get to the bottom of his problem; and Nurse Hoffel puts in motion her diabolical plan.
To solve a serious shortage, Dean Munsch and Chanel start a blood drive. Meanwhile, Nurse Hoffel's plan for revenge is put in motion; Hester comes up with a way to join the hospital staff; and a jarring revelation about the Green Meanie is uncovered.
The frightful events of Halloween force Dean Munsch to notify authorities of murders at the Institute, which leads to a surprising influx of new patients. Meanwhile,Chanel is tired of doing dirty work, so she concocts a plan that entails recruiting new patients to join the Chanels. Later, Zayday and Chanel #5 visit a person with ties to the hospital's past; and a new patient's problems have the staff going a bit mad.
The Green Meanie's latest attack shocks everyone, so Dean Munsch, Denise and Hester plan to catch the killer by throwing a Halloween party in the hospital. Meanwhile, Chanel attempts to contact the killer's latest victim from beyond the grave. Back at the party, another outbreak puts the hospital on alert and Brock and Cassidy jump into action, while another victim falls.
Dean Munsch, Denise and the Chanels question Hester about the killer, as well as the sole survivor of the Halloween massacre, while Chad believes Brock to be the culprit and makes a shocking proposal to Chanel. Later, a patient arrives with an incredible disorder that leads Chanel #3 and Cassidy to become closer.
A patient with a horrible ailment checks into the hospital with hopes of a cure, but instead finds a love interest. Meanwhile, Chad arrives hoping to win back Chanel, but uncovers a disturbing secret about Brock; and Munsch has another encounter with the killer and recruits a new special agent to investigate.
In the Season 2 premiere, it's years after the horrors of Kappa House, and Dean Munsch buys an abandoned hospital, where she recruits Drs. Brock Holt and Cassidy Cascade, and medical student Zayday Williams, plus the disgraced Chanels. And soon a new killer stalks the facility.