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The bridges connecting Roosevelt Island are destroyed by a set of explosions to cut all access to the mainland. War erupts among the Animus and Dolore, as casualties arise from both sides. Herv?, with Anna in his arms, breaks into the school grounds. The four girls follow in pursuit and find Lise at the school.
It is Christmas Eve, and each of the girls spends the night in company of their loved ones. As the sun rises in the morning, all four bid their last farewell and gather at the school to prepare for the upcoming battle.
Herv? and Emilio infiltrate Vivaleo Pharmaceuticals as well as Lula, Rachel, Rose, and Claire. Emilio creates a commotion in the lab to help Kate and Lise escape, but Kate won't go because she deems him a liar. Herv? goes to find Anna, but she is held in custody by his grandfather, Lauro.
Inspector Neil dials Kate to inform that he saw Lise alive but in custody of a group of men. As he is following the vehicle transporting Lise while at Brooklyn Bridge, it loses control and crashes. Meanwhile, Kate does a search on Vivaleo Pharmaceuticals and phones Herv? to demand Lise's return, but the conversation is cut when a group of Dolore men kidnaps Kate and brings her to Dr. Bender.