Sam's assignment is to capture his former high-school biology teacher, whom everyone loathed. Meanwhile, Nina emits pheromones that attract other demons from around the globe, and Ben attempts to fight them off.
Nina moves in with the guys after her place burns down. Unfortunately, so does Morgan, who flirts with Nina and puts Sam in an awkward position. Meanwhile, Sock throws a party at the Work Bench, but it doesn't go quite as planned.
The Devil sends Sam an attractive tutor to train him for the end times, but Sam plans to seduce her to gain information about how to defeat Satan. Meanwhile, Nina decides to take revenge against Ben and Sock.
Sam agrees to help Alan relocate to the Vatican, where he will be safe from the Devil---but only if Alan will explain how he won his soul back. Meanwhile, Nina tries to persuade Ben to let her meet his family, and the Devil causes Sam and Morgan to be at odds with one another.
The guys go on a road trip to locate an escaped soul, and they encounter a tentacled beast that is taking over a small town and is eager to dine on them. Meanwhile, Ben tries to give Nina more freedom, and Sock attempts to sleep with his stepsister.
The Devil orders Sam to teach his spoiled son, Morgan, to have a stronger work ethic so he can take over the family business. Sam reluctantly takes Morgan with him to capture an escaped soul. Meanwhile, Ben believes Nina is turned off by his human form, and Sock uses Ted in a scheme at the Work Bench.
Sam must send a 1950s boxer back to hell by getting into the ring with him and knocking him out. Meanwhile, Ben fears his friends won't accept his new girlfriend because she's a demon, and Andi discovers that Sock created a fake employee at the Work Bench so he can collect a double salary.
The second season begins with Sam, Sock and Ben returning from vacation only to discover that they have all been fired from the Work Bench and evicted from their apartment. Later, Sock learns that he has a gorgeous stepsister, and the Devil orders Sam to capture an escapee from hell who broke a deal with him.