Baton Rouge paramedics rush to the aid of a man attacked by his girlfriend with a box-cutter knife. Gunshots fired in Yonkers send Ariel and Cunningham to save a man down. Meanwhile, in Austin, first responders Kim and Audrey plead with a patient to go the hospital before she has another potentially life-threatening seizure.
In Baton Rouge, a brawl erupts in the back of Meghan and Dee's ambulance when an overdose patient wakes up swinging. Meanwhile, Ariel and Cunningham fear the worst as they rush to the scene of a flaming motorcycle wreck in Yonkers. And in Austin, when a truck swerves out of control, Kim and Audrey hope to find its missing driver at the bottom of a ravine.
In Austin, Texas, a man is shot by someone he trusts. Meanwhile, in Yonkers, New York, Cunningham and Ariel face an emotional call that hits too close to home. The Baton Rouge community is hit hardest when Niki and Nicole are faced with the task of trying to save a life of a fellow service member.
In Austin, Luddy and Finch practice parking lot medicine when responding to a heroin overdose. Niki and Nicole show empathy to a young woman suffering from emotional trauma in Baton Rouge. Yonkers medic Alex reveals a sobering truth about her past.
Yonkers first responders Alex and Jamal face unexpected challenges when they respond to a call for a man with a broken ankle who fell from a fire escape. The night really starts to heat up for Steven Lopez and Sam Netheron in Tucson when they are called to a structure fire and must search inside for possible victims. Things get personal for Niki Johnson in Baton Rouge when a call for a patient with back pain takes an emotional turn.
In Baton Rouge, Lacey and Stacey restrain a patient suffering from violent hallucinations after overdosing on the synthetic drug Mojo. Meanwhile, Matt and Henry face the most difficult challenge paramedics encounter when an Austin man calls 911 to save his wife from cardiac arrest. And in Yonkers, New York, Alex and Jamal must determine what drug caused a woman to go unresponsive before her heart stops beating.
In Austin, Texas, responders run point in a massive multiple car collision and need to triage more victims than can fit into their ambulance. A combative addict and an overdose gone wrong offer tough challenges in Yonkers, New York, while in Baton Rouge, Louisiana, southern charm is revealed to have its own healing effects. And in Tucson, Arizona, responders do everything they can to avoid delivering a baby in the back of their ambulance.