Matron Luckes insists that Ada Russell attend a meeting with the elderly Florence Nightingale; expert surgeon Mr. Dean returns to the operating theater; fire strikes a sweatshop and scores of children are injured.
Ethel hastens to a naval hospital to be at the side of her dying brother, and Dr. Culpin is despondent because he is powerless to help; expert surgeon Mr. Dean is given an ultimatum concerning his drug use; Sister Russell sneaks out of the London to aid a young mother.
A nurse trainee is caught sneaking out for a rendezvous with a mysterious young man; a woman arrives attired in pauper's clothing but sporting underwear made of silk; pioneering Dr. Henry Head risks performing a dangerous experiment on himself.
Sister Ada Russell is overwhelmed by her intensive involvement in the hospital; polio sends a youngster to the Hebrew Wards; Nurse Goodley is drawn to charismatic radical Saul Landau, despite his battle with a life-threatening illness.
Nurse Bennett believes that her alliance with Dr. Culpin has been uncovered as Matron Luckes reassigns her to private nursing. Meanwhile, Chairman Holland suspects that a new wonder drug may not be as wonderful as originally thought.
Season 2 opens as victims of an explosion are rushed to the hospital, where plainclothes policemen seek to determine whether the blast was the work of anarchists, Fenians or suffragettes. Elsewhere, star surgeon Percy Dean returns unexpectedly, and a lad dies under anesthesia.