In the series finale, Nick must look to his ancestors for strength to save the world from a terrifying end as he faces off against a seemingly unbeatable foe. At the Spice Shop, Monroe, Rosalee and Eve search for answers and stumble upon a rare potion that may help the fight. Elsewhere, Capt. Renard and Adalind try to keep Diana and baby Kelly safe as the threat has its eyes set on the children.
The prophecy that was uncovered comes to pass when a dark force arrives in Portland with its eyes set on Diana. In an effort to protect her, Nick, along with Capt. Renard and Adalind, returns to the scene of his first investigation as a Grimm. Back at the Spice Shop, Monroe, Eve and Rosalee make a discovery that uncovers the origins of the mysterious stick. Meanwhile, Hank and Wu are called to a crime scene that is connected to the gang's greatest threat.
A mysterious portal takes Eve and Nick on a surprising journey. Meanwhile, an uneasy alliance is established when Capt. Renard is brought in to help and discovers this all may be connected to the person he cares for the most.
A string of brutal deaths may be tied to an unlikely perpetrator found by Nick and Hank in a local nursing home. Meanwhile, Eve goes to Adalind to get answers that only a Hexenbiest can provide. Elsewhere, Capt. Renard confronts Nick about the mysterious symbols and tries to strike a deal.
A man claims his friend was consumed by a treelike figure; and the gang learn of Eve's disturbing mirror encounter, which leads everyone to take extra precautions. Meanwhile, Capt. Renard tries to determine what Diana was drawing.
Deadly attacks on scientists lead Nick, Hank and Wu on an investigation unlike any they have had before. Meanwhile, as the research continues into the origins of the cloth, Monroe and Rosalee learn that Eve is feeling the aftereffects of the death grip. Elsewhere, Capt. Renard reaches out to an old friend to get answers to the origins of the symbols drawn by Diana.
Rosalee surprises Monroe with a getaway for his birthday and invites most of the gang to join them. Things take a shocking turn, though, when a hotel employee targets Nick in an effort to avenge his father. Meanwhile, Eve gets a visit from a dark force that she has seen before; and Capt. Renard's weekend with Diana is interrupted when a former ally decides to get even.
A mysterious Wesen turns sleepless nights into pure insanity. The investigation begins when Nick, Hank and Wu are called to a local hotel where a grisly murder has taken place, which leads them to a guest who claims to be haunted by a frightening creature. Meanwhile, at the Spice Shop, Monroe, Rosalee and Eve continue to research the origins of the symbols on the cloth; and Capt. Renard finds it difficult to escape his past transgressions.
A new Wesen with a deadly hunger is unearthed after lying dormant for seven years; at the same time, Nick, Hank and Wu investigate a bizarre murder in a local park. Meanwhile, Capt. Renard continues to be haunted by a ghost from his past; Monroe and Rosalee seek a doctor's opinion on whether Diana's premonition is true; and an extremely weak Eve is found in the tunnels by Adalind.
Nick, Hank and Wu investigate a terrifying clairvoyant Wesen who has his eyes set on terrorizing a young family; Capt. Renard is left reeling from the appearance of an unexpected guest; Diana has some interesting news for Monroe and Rosalee; and Eve returns to the catacombs beneath Nick's loft to search for answers to her bizarre visions and side effects from being healed by the mysterious stick.
Adalind and Monroe do everything in their power to see that Nick's clever plan to get under Capt. Renard's skin goes off beautifully. Meanwhile, Eve and Rosalee are under the gun to get their spell ready on time.
Nick makes a pact with potentially deadly consequences; Hank and Wu think they have a way to stop Renard; a phone call throws Adalind into the middle of everything; Diana demonstrates her power while in the care of Monroe and Rosalee; and Eve and Trubel do some digging to figure out the mystery of the cloth found with the healing stick.
In the Season 6 premiere, a shoot-to-kill manhunt is ordered by Capt. Renard, who's hell-bent on eliminating Nick once and for all after the loft massacre. Meanwhile, Monroe and Rosalee have mixed feelings about staying in Portland now that their family is expanding; and Eve deals with the side effects of the mysterious stick's healing power.