Jon Stewart hosts the 44th annual gala at the Staples Center in Los Angeles. Slated performers include U2, Dave Matthews Band, Alicia Keys, 'N Sync, Nelly, Bob Dylan, Tony Bennett, Billy Joel, Outkast, Joshua Bell, Alan Jackson, Destiny's Child, Alejandro Sanz and Train, along with Christina Aguilera, Lil' Kim, Mya, Pink and Missy Elliott ("Lady Marmalade"). Also: artists from the "O Brother, Where Art Thou?" soundtrack are featured, including Emmylou Harris, Alison Krauss and Ralph Stanley.