Part game show, part reality TV. An animated canine plays host to children who face challenges, some dealing with science. Unscripted live-action mixes with animation in a series aimed at ages 6 to 10.
In the Season 5 finale, Ruff learns that Purrs, the group behind "Go Get It," is plotting to brainwash everyone into thinking they're felines---and that it's responsible for his parents' disappearance. He sends the contestants to figure out how to break into the Purrss HQ, which is in a water park.
Ruff decides to competes against "Go Get It," a rival game show by cats, in a synchronized-swimming match. To prepare, he sends Marco, Shreya, and Rubye to learn about synchronized swimming, and Marc to an aquarium to learn about beluga whales.
To prepare for a family-reunion barbecue that will include distant wolf relatives, Ruff sends Emmie and Rubye to Yellowstone National Park to learn about wolves, and Jay and Marc to South Carolina to learn about Southern barbecue.
Ruff's rock-star cousin Rüf Rüfman wants songbirds on his next album, so Ruff sends Emmie and Rubye to the field to work with songbirds. He also assigns Marc and Shreya to meet a hand model because of a mix-up between the word hands and the name Hans.
Ruff wants to make a recent dream---in which he was flying with an elephant---come true. So he sends Marco to an elephant sanctuary to learn how to care for elephants, and has Marc and Rubye learn to skydive indoors.
Ruff believes a sarcophagus he found in his backyard contains a cursed Egyptian mummy, so he sends the kids to a museum to carbon date the mummy to prove his hunch. Along the way, the kids enjoy an Egypt-theme amusement park.
Ruff needs a vehicle so he won't have to run when playing fetch with his owner, so he asks Emmie and Shreya to build him one. He also assigns Jay and Marco a difficult task: invent a device that will make his life easier.
Grandma Ruffman stops by. Because her friends are getting married, she sends Rubye and Jay to make a bear-proof picnic basket, which she wants to give as a wedding gift. Meanwhile, Shreya, Emmie, Marc and Marco bake the wedding cake.
Ruff sends Emmie on a cheese-theme challenge. He also decides to use a carrier pigeon to find his long-lost parents, so he sends Jay and Rubye to learn about carrier pigeons, then compete in a race against one.
Ruff learns from his pal Crush, the sea turtle in "Finding Nemo," that turtles are in trouble. So he sends Marco and Shreya to Florida in order to learn about turtles and help turtle hatchlings on the beach. He also has Jay appears on a radio game show.
When Ruff learns his cousin Bluff Ruffman is sending animals to the doghouse, he has Marco and Shreya learn how to care for animals at Disney's Animal Kingdom. He also sends Rubye to Las Vegas to learn magic from Penn and Teller so that, if anything goes wrong, he can make the animals disappear.
Ruff finds his lost contestants on mysterious Game Show Island, but in order for them to leave the isle they must to find relics from the "Fabulous Four" game show by sundown. Ruff also digs up clues about his parents' mysterious disappearance.