Kelly Ripa and Regis Philbin courtesy Disney-ABC Television Group Kelly Ripa and Regis Philbin courtesy Disney-ABC Television Group

Talk-show host, soap alum, übermom, sassy spouse... and Ugly guest? Kelly Ripa's résumé just got one line longer.

On Ugly Betty's Sept. 25 season opener, Ripa and Live cohost Regis Philbin will be grilling "Mode" editors Wilhelmina (Vanessa Williams) and Alexis (Rebecca Romijn) when they appear on their daytime talker.

Not to be outdone, Ripa is beating her hunky hubby, Mark Consuelos, to the punch - as we reported last week, he'll be appearing on the new season's third episode. But will there be some kind of tie-in between Ripa and Consuelos' Ugly stints? That remains a mystery.

Tell us - would you like to see the real-life spouses together on Ugly Betty? And if so, playing whom? - Nina Hämmerling Smith