Ellen Pompeo and Patrick Dempsey Ellen Pompeo and Patrick Dempsey

Grey's Anatomy kicks off its 11th season — in a new time slot! — on Thursday, so what's in store for the docs at Grey Sloan Memorial?

Answer: Plenty of drama — both at home and at work. Would you expect anything less?! We know that Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) will deal with their fair share of ups and downs as he mulls a move to Washington, D.C., and that Callie (Sara Ramirez) and Arizona (Jessica Capshaw) may find themselves on the rocks again as they deal with trying to have a baby through a surrogate.

Quiz: How well do you know Grey's Anatomy?

It remains to be seen how acutely the absence of Cristina Yang (Sandra Oh) will be felt, both by the characters and the show's viewers, but some new faces are also coming into the mix. Caterina Scorsone has been promoted to series regular as  Dr. Amelia Shepherd (Derek's sister/Owen's new love interest??), and Kelly McCreary will also be back as Dr. Maggie Pierce (Meredith's sister/Richard's daughter).

Click here for a refresher on where we left off with the hospital staff, plus teasers from series creator Shonda Rhimes about what's ahead.

What are you looking forward to in Season 11, Grey's fans? Sound off in the comments!

Grey's Anatomy premieres Thursday at 8/7c on ABC.