According to TVLine, the trio will probably appear in Episode 10 of Castle's current eighth season, the second episode after the show returns from its winter hiatus. DePaiva and Watkins will likely play a married couple who get roped into a murder investigation, and it's unknown who Vogel will play.
DePaiva shared the news via Twitter on Friday, noting that she and Watkins were reuniting with their former OLTL co-star, Nathan Fillion, who played a young Joey Buchanan on the ABC soap.
DePaiva starred as Blair Cramer on One Life to Live, while Watkins played David Vickers and Vogel played Dr. Melanie McIver.
Castle airs on Mondays at 10/9c on ABC.
Are you looking forward to the One Life to Live reunion?