Popular radio crooner Rudy Vallee plays the head doctor at a very unusual clinic, Dr. Vallee's Musical Hospital. As the short opens, a Nurse (Mae Questel) is manning the oversized, organ-like switchboard, telling a persistent caller that Dr. Vallee is in conference. That conference is with a group of young doctors preparing to start work. Vallee instructs them in rhyme and then in song to "Keep a Little Song Handy," a sentiment that the doctors echo back. The doctors start on their rounds, and in one ward we discover a man who screams about Pagliacci while being treated with numerous water bottles. Another one keeps jumping around, and the young doctors misdiagnose it as indigestion, mumps and hammertoes. Vallee tells them it's musical starvation, and prescribes a strict diet of such items as cheer-up ditties, a salad of light ballads, a classical appetizer, etc. Vallee then is told that an emergency is on its way, and he heads to the operating room, where he operates by singing a few bars of "Mammy" for the patient (after anesthetizing him with a lullaby), then ends the day by singing to the other patients over a TV transmitter.