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Wesley Littlejohn (Billy Jacoby) is a nerd whose life takes a dramatic turn when gorgeous substitute biology teacher Ms. Xenophia (Judy Landers) selects him for some extra-credit research after school. Wesley goes to Ms. Xenobia's lab; her assistant, Drax (Raymond O'Connor), jabs a needle into his rear; and Wesley is a changed boy. For all its gratuitous soft-core sex, DR. ALIEN is for the most part dull. Much of the film is merely an excuse for displaying Landers and several other attractive women in sexy lingerie, but the effect falls flat because of Dave DeCoteau's meandering direction.