Tyrion and Cersei Lannister (Peter Dinklage and Lena Headey), Game of Thrones
Drink of choice: Wine
Although both siblings love their wine (being a Lannister has its stresses), Cersei breaks the cardinal rule of inebriation and is an angry drunk. Give that lady a goblet and let the slurred barbs fly! At least her little brother Tyrion makes an effort to be entertaining. He's quite the self-deprecating raconteur, such as when he tells his newlywed bride, "I vomited on a girl once in the middle of the act, not proud of it. But I think honesty is important between man and wife, don't you agree? Come, I'll tell you all about it, put you in the mood." Um, cheers?