The star of the Superman movies from 1978 to 1987 played Dr. Virgil Swann, a founding member of the Veritas Society, which was formed to protect the Traveler (aka Clark Kent).

The actress, who portrayed Lois Lane on the ABC series Lois & Clark: The New Adventures of Superman (1993-97), took on the role of Ella Lane, Lois' mother.

Lois Lane in the Reeve films between 1978 and ‘87, she played Dr. Bridgette Crosby, assistant to Dr. Swann and member of the Veritas Society.

The title character in the 1984 movieSupergirl, she portrayed Lara-El, Clark's birth mother.

Clark Kent to Teri Hatcher’s Lois in Lois & Clark, he took on the role of Dr. Curtis Knox, an immortal doctor who was harvesting Kryptonite-infected body parts from meteor freaks.

The Vampire Diaries star filled the part of Lucas Luthor, Lionel Luthor's illegitimate child, who helped Lex expose Lionel.

The Vampire Diaries and Lost star played Adam Knight, a resurrected teenager sent by Lionel Luthor to spy on Lana and Clark.

TV’s Wonder Woman in the 1970s played Chloe’s mother Moira, who had the ability to control other meteor-infected people.

The 90210 star played John Corbin, who, after being run down by a bus, was built into Clark's nemesis, Metallo.

The 90210 star played Linda Lake, a Daily Planet gossip columnist hell-bent on exposing Clark Kent as the Blur.

Before starring on Lost, the actress appeared in three different episodes, including the Season 1 episode "Kinetic," in which she was Wade's girlfriend.

Best known for his role on Buffy, he played Professor Milton Fine, who turned out to be Brainiac, the Kryptonian artificial intelligence who was corrupted by General Zod.

The Star Wars actress played Pauline Kahn, the Daily Planet editor-in-chief, who initially denied Chloe a job there.

Before starring on Supernatural, he played Jason Teague, Lana's boyfriend who was on the hunt for the Stones of Power.

The Dr. Quinn, Medicine Woman star played Genevieve Teague, mother to Jason, and a descendent of Duchess Gertrude, whom Margaret Isobel Thoreaux, the countess who possessed Lana, was destined to murder.

The Dukes of Hazzard brothers reunited when Wopat played Jack Jennings, a Kansas state senator and old friend of Jonathan's.

The Enchanted star played Jodi Melville, an overweight teenager who quickly shed her pounds by drinking a power shake with meteor rock-infected vegetables.

The 7th Heaven star played Zan of the Wonder Twins, who were the Blur's groupies.

The OC star portrayed Geoff Johns, a meteor freak with the power to paralyze people, like Lois Lane, whom he kidnapped.

The blaxploitation actress played Agent Amanda Waller, the manipulative head of Checkmate.

The actor, best known for his role in Stargate SG-1, played Hawkman, the leader of the Justice Society of America.

The star of A Room with a View portrayed the clone of Jor-El in Season 9. Terence Stamp, who played General Zod in the first two Superman films, provides the voice of Jor-El in the Fortress of Solitude.

The real-life husband of Smallville's Annette O'Toole, who also starred in This Is Spinal Tap, played Perry White, the eventual Editor-in-Chief of The Daily Planet.

Ironside, who coincidentally provided the voice of Darkseid in Superman: The Animated Series, portrayed Lois' father, General Lane, while FlashForward's List played her sister, Lucy.

The Battlestar Galactica star played Slade Wilson, the General who enforced the Vigilante Registration Act and tried to enslave the heroes.