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Gossip Girl Greys Anatomy House and more

Shaun Harrison
1 of 9 Eric Liebowitz/The CW


When the CW's Gossip Girl returns on April 21... Blair is on the warpath (beware, Jenny!), and we just may find out what really sent Serena running off to boarding school.
2 of 9 Will Hart/NBC


When NBC's Law Order returns on April 23...Jesse L. Martin's Det. Green exits via a "disturbing" storyline. Lupo's new partner K-Ville's Anthony Anderson.
3 of 9 Sergei Bachlakov/The CW


When the CW's Supernatural returns on April 24...After a quirky episode spoofing reality TV, the season-ending stretch will focus on "the culmination of Dean's deal to go to hell," says creator Eric Kripke.
4 of 9 Ron Tom/ABC


When ABC's Grey's Anatomy returns on April 24..."Old relationships will become new again, people you thought would never get together will, and there are going to be interesting outside influences," says creator Shonda Rhimes.
5 of 9 Michael Desmond/ABC


When ABC's Ugly Betty returns on April 24..."All of the new episodes are going to have a twist and a turn and a shock," says creator Silvio Horta. "And the storylines are going to be deeper, honing in on Betty's point of view."
6 of 9 Cliff Lipson/CBS


When CBS' Moonlight returns on April 25...Viewers will learn more about Mick's past and watch him struggle to win back Beth. Entering the murky mix A new romantic foil (Brothers Sisters' Eric Winter).
7 of 9 Isabella Vosmikova/Fox


When Fox's House returns on April 28...House's cases include a "really, really nice" patient and a soap star who doesn't know he's sick. It leads to a two-part finale that will affect every character "in a personal way," says creator David Shore.
8 of 9 Jack Rowand/The CW


When the CW's Reaper returns on Tuesday, April 22...Steve and Tony try to lure the Devil into a trap. Also, a desperate Sam asks the Devil for a favor, totally underestimating what he'll be asked for in return.
9 of 9 Monty Brinton/CBS


When CBS' Shark returns on Tuesday, April 29...Stark is angry and bitter after being disbarred in California. But... a twist of fate gets him his license back.