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TVGuide.com readers share their picks

1 of 17 Jordan Strauss/WireImage.com

Christian Slater

"Christian Slater would be a cool choice." — basic315140
2 of 17 Stefanie Keenan/Getty Images

Balthazar Getty

"Balthazar Getty from Brothers and Sisters... He looks and sounds just like Charlie." — BetsyofTexas
3 of 17 Theo Wargo/WireImage.com

Michael J. Fox

"How about Michael J. Fox? It would be a great way to end the show, as Sheen replaced Fox on Spin City. Fox can still act (he was unctuous as hell on The Good Wife) and there would be an immediate positive buzz." — jdavis3
4 of 17 Bennett Raglin/WireImage.com

Matthew Broderick

"How about getting Mathew Broderick as Jon [Cryer] is confused for him in real life. That might be interesting casting." — DarylZer0
5 of 17 Carlos Alvarez/Getty Images

Emilio Estevez

"Emilio Estevez would make it an interesting show to watch for a number of reasons..." — Cyclop
6 of 17 Phillip Massey/WireImage.com

Martin Sheen

"Only ONE man can replace Charlie in this VITAL role... MARTIN SHEEN!" — BlueSeed1
7 of 17 Denise Truscello/WireImage.com

Ted McGinley

"Ted [McGinley], duh. That's his job... replacing departed sitcom characters. He's the patron saint of shark-jumping" — lwingo
8 of 17 Jason Merritt/FilmMagic.com

Rob Lowe

"Rob Lowe is hilarious and would make a good replacement but only if they change the basic character: he cannot be another Charlie. That character was wired to self destruct and nobody wants him back after this mess. They should create a new character around Lowe's own comedy. I never watched the show but I would watch it if Lowe were the new lead." — lily1
9 of 17 Steve Granitz/WireImage.com

Will Arnett

"If they want to keep a similar dynamic, bring in Will Arnett who's hysterical and plays a great smug, egotistical, party-er type who'd be irritated as all get out by someone like Cryer's character." — Amore22
10 of 17 Stephen Lovekin/Getty Images

Tom Cavanaugh

"Tom Cavanaugh would be an amazing choice. He's already proven he's got comedy chops, both verbal and physical. He'a certainly got a look that I think would attract attention to the show and sometimes a 'dark horse" choice is better than that usual list of suspects!" — SetScotlandFree
11 of 17 Dr. Billy Ingram/WireImage.com

Henry Winkler

"I think Henry Wrinkler (The Fonz) should move in as Alan's ex-father-in-law, so he can be close to his grandson. With the writers and the wits of both [Cryer] and Henry, this show would again be on top." — jerryd369
12 of 17 Jeff Kravitz/FilmMagic.com

Gary Busey

"Gary Busey could easily replace Charlie Sheen." — Chappel
13 of 17 D Dipasupil/WireImage.com

Jason Bateman

"Give Jason Bateman a job. Hire anyone good and morally responsible to play a part. Or else cancel the show for good. It's not that great." — RebeccaMcKenna
14 of 17 Eric Charbonneau/WireImage.com

Robert Downey Jr.

"My first thought was Robert Downey Jr., but he is too big of a star." — trisha57
15 of 17 Jason LaVeris/FilmMagic.com

John Stamos

"Both Rob Lowe and John Stamos would be good for the part, but I think John Stamos would be a better choice." — LupeAlvarez
16 of 17 Brian Killian/WireImage.com

James Spader

"I would love to see James Spader in anything. He was great with Denny Crane [on Boston Legal], but wouldn't mind Robert Downey Jr. They're both terrific actors and better than Sheen. I hope the show continues." — trombone
17 of 17 Greg Gayne/Warner Bros. Television; Troll Company

A Troll

"Who should replace Charlie Sheen? A TROLL. — sauly001