Premieres: Wednesday, Sept. 22, 8:30/7:30c Sisters Maddie (Jennifer Finnigan), a high-strung attorney, and Mia (Privileged's JoAnna Garcia), a free-spirited "inventor," are fundamentally different. Maddie lives with, but has not married, Ben (Josh Cooke), her boyfriend of nine years. "It's a valid life choice," she repeats throughout the pilot. Mia, on the other hand, has just agreed to marry Casey (Jake Lacy), her boyfriend of seven-and-a-half weeks. Kurt Fuller and Debra Jo Rupp play the girls' quirky parents.

Premieres: Friday, Sept. 24 at 10/9c Crime-fighting meets family squabbling in this procedural about the Reagans, a multigenerational clan of New York cops. Frank (Tom Selleck), is the chief of police, just like his dad was. Frank's eldest son, Danny (Donnie Wahlberg), is a gruff detective and Iraq War vet; his youngest son, Jamie (Will Estes) is a rookie cop fresh out of the academy. Bridget Moynahan rounds out the testosterone-heavy cast as Frank's daughter, Erin, an assistant district attorney and single mom.

Premieres: Sunday, Sept. 19, 9/8c Steve Buscemi stars as Enoch "Nucky" Thompson, a corrupt politician in 1920s Atlantic City. Michael Pitt, Kelly Macdonald and Gretchen Mol co-star. Among the show's executive producers are Terence Winter (The Sopranos) and Martin Scorsese, who directed the pilot.

Premieres: TBD, Fridays at 9/8c Dr. Megan Hunt (Desperate Housewives' Dana Delany) plays a feisty neurosurgeon whose career ends after a car accident. She takes a job as a medical examiner in Philadelphia, where she helps cops solve murders by "reading the body."

Premieres: Monday, Sept. 20 at 10/9c Kelli Giddish stars as a tough-talkin' U.S. marshal in this adrenalized action series from Jerry Bruckheimer.

Premieres: Wednesday, Sept. 22 at 10/9c Nick Morelli (Jim Belushi) and Pete Kaczmarek (Jerry O'Connell) are colorful Las Vegas defense attorneys who risk it all for their clients in this legal dramedy (think Boston Legal). Co-starring Tanya Fischer as the firm's colorful assistant, Sophie, and Jurnee Smollett as Lisa Tyler, a new associate who paid his law-school tuition by stripping.

Premieres: Tuesday, Sept. 21 at 10/9c Michael Imperioli stars as a respected but misunderstood homicide detective. In the style of Southland, the show follows the cops as they police the streets of Detroit, the city with the country's highest murder rate. Jon Michael Hill, James McDaniel, Aisha Hinds and Natalie Martinez also star.

Premieres: Monday, Sept. 20 at 9/8c A presidential assassination attempt, a missing person and a CIA cover-up are among the events that aren't the event of this mystery thriller's title.

Premieres: TBD Sarah Shahi (Life) stars as the titular Kate Reed, a talented litigator who, tired of unjust bureaucracy, becomes a mediator, aka the anti-lawyer. While Kate settles everyone else's affairs, her own life is complicated by entanglements with her newly widowed stepmother/boss (Virginia Williams) and her ex-husband (Battlestar Galactica's Michael Trucco).

Premieres: TBD Jared Franklin (Breckin Meyer) and Steven Bash (Mark-Paul Gosselaar) are ambulance chasers who create a stir when they join a white-shoe law firm. Malcolm McDowell plays their buttoned-up boss.

Premieres: TBD Four friends (Kelly Blatz, Callard Harris, Matt Bush, and Drew Seeley) pledge a fraternity together in the 1980s. Saturday Night Live vet Tim Meadows headlines as a college professor; Teri Polo (Meet the Parents) also stars.

Premieres: Monday, Sept. 20 at 10/9c This action-packed remake of the hit procedural stars Alex O'Loughlin as Steve McGarrett, a detective who heads back to the Aloha State to investigate his father's murder. The governor (Jean Smart) enlists him to form an elite task force, which includes Detective Danny "Danno" Williams (Scott Caan), Chin Ho Kelly (Daniel Dae Kim) and Chin's cousin, surfer-turned-cop Kona (Grace Park). You'll recognize the theme song.

Premieres: Wednesday, Sept. 8, 9/8c Marti Perkins (Aly Michalka) wants to go to law school, but she's flat broke. So the amateur dancer reluctantly applies for a cheerleading scholarship to help pay her tuition. Ashley Tisdale (the High School Musical flicks) co-stars as Marti's prim roommate Savannah. Smallville's Tom Welling executive-produces.

Premieres: Wednesday, Sept. 22 at 10/9c By now, we all know the premise. Nevertheless, NBC promises that this won't be your grandfather's Law & Order, as it'll feature a comely, youthful cast squeezed between that signature sound effect. First up: Skeet Ulrich has signed on in one of the detective roles.

Premieres: Monday, Sept. 20 at 9/8c Newcomer James Wolk stars as a Texas con man who, as Bob Taylor, has a wife in Houston (Adrianne Palicki) and, as Robert Allen, a girlfriend in Midland (Eloise Mumford). Robert/Bob navigates this double life with a precision (two wallets, two cellphones) he learned from his con-man dad (the always solid David Keith), but is always worried that his blustery oil magnate father-in-law (Jon Voight) will discover his secret.

Premieres: Monday, Sept. 20 at 9:30/8:30c Chicago cop Mike (Billy Gardell) and schoolteacher Molly (Melissa McCarthy) meet at an Overeaters Anonymous group. Their attraction is instant.

Premieres: Thursday, Sept. 23, 8/7c In 2000, a documentary film crew follows a group of Austin, Texas, high school students just as they're graduating. When they revisit the same classmates 10 years later, guess what? They've changed!

Premieres: Thursday, Sept. 9, 9/8c Maggie Q (Mission: Impossible 3) plays the titular assassin, who wants to bring down a secret government program that turns at-risk youth into killers.

Premieres: Tuesday, Sept. 28 at 8/7c Jim and Stephanie Powell (The Shield's Michael Chiklis and Dexter's Julie Benz) are an average couple who, along with their kids, develop some "super" abilities when a family vacation ends with a plane crash in the Amazon River. Romany Malco and Autumn Reeser co-star.

Premieres: Friday, Sept. 24 at 10/9c Supreme Court Justice Cyrus Garza (Jimmy Smits) suddenly resigns when he realizes the system is flawed. The playboy and gambler returns to private practice to help the little guys take on the system.

Premieres: Thursday, Sept. 23 at 9:30/8:30c An American (newcomer Ben Rappaport) moves to India to run a call center for a novelty company. There, ethnic stereotypes — both Indian and American — are challenged.

Premieres: Tuesday, Sept. 21 at 9/8c The significantly named Jimmy Chance (Lucas Neff) becomes a single dad at 23 when a one-night stand announces she's pregnant and will be unable to care for the baby. Martha Plimpton, Garret Dillahunt and Cloris Leachman co-star.

Premieres: Tuesday, Sept. 21 at 9:30/8:30c Emotionally stunted rich guy Steve Wilde (Will Arnett) desperately tries to impress his childhood crush Emmy (Keri Russell), who's now an uber-liberal humanitarian with a 12-year-old daughter who doesn't speak.

Premieres: TBD, Fridays at 8/7c Wealthy people go undercover in some of the most dangerous communities in the country to find the unsung heroes who help those in need on this reality show. At the end of a week, they reveal their identity and donate $100,000 to deserving individuals and organizations.

Premieres: Thursday, Sept. 23 at 8:30/7:30c Ed (William Shatner), a politically incorrect curmudgeon, harangues his youngest son, Henry in this Twitter feed-turned-sitcom. MadTV vets Will Sasso and Nicole Sullivan co-star.

Premieres: TBD Top Chef judge Gail Simmons hosts this competitive culinary spin-off in which pastry chefs compete in a series of dessert challenges. Famed pastry chef Johnny Iuzzini serves as head judge.

Premieres: Wednesday, Sept. 22 at 8/7c Think Mr. & Mrs. Smith, the TV show. Married former spies (Boris Kodjoe and Gugu Mbatha-Raw) get back in the family business together in the J.J. Abrams-produced action series.

Premieres: Wednesday, Sept. 22 at 10/9c Rob Morrow and Maura Tierney star in this legal drama which examines a case from both the defense and prosecution's perspectives.