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After playing perennial leader Dr. Jack Shephard, Fox hit London's West End in In a Forest, Dark and Deep. He went on to play the villain in Alex Cross and last appeared in Brad Pitt's zombie flick World War Z.
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Following his role as the loveable unlucky lottery winner Hugo "Hurley" Reyes, Garcia had bit parts on How I Met Your Mother, Fringe and Californication. He also starred in Alcatraz before finding a home on Once Upon a Time, where he plays a giant named Anton. He recently reunited with Daniel Dae Kim on Hawaii Five-0 and has since been promoted to series regular.
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Andrews, who played former Iraqi Republican Guard Sayid Jarrah, mostly fell out of the spotlight following Lost. He recently starred opposite Naomi Watts in the Princess Diana biopic. He also reunited with Lost scribes Adam Horowitz and Edward Kitsis on their Once Upon a Time spin-off, Once Upon a Time in Wonderland.
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Holloway's James "Sawyer" Ford had a knack for nicknames and stirring up drama, but after Lost, the actor took on more badass roles, like his brief, but awesome appearance in Mission: Impossible — Ghost Protocol and his starring role on CBS' midseason drama Intelligence.
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Daniel Dae Kim
Kim, who played Jin Kwon on the ABC island series, stuck around Hawaii for CBS' Hawaii Five-0 reboot, on which he plays Chin Ho Kelly.
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After playing Jin's dedicated wife Sun Kwon, Kim returned to star in ABC's remake of the popular UK guilty pleasure series Mistresses, on which she plays a psychiatrist who slept with one of her patients.
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O'Quinn, who played John Locke, returned to Hawaii alongside Daniel Dae Kim for a guest run on Hawaii Five-0 before landing a starring role in the short-lived 666 Park Avenue. He also had a short role on Falling Skies and joined new Fox midseason drama Gang Related.
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Following her days as Kate Austin, Lilly went on to co-star in Real Steel with Hugh Jackman before landing the role in Peter Jackson's adaptation of The Hobbit as the elf Tauriel — a character not in the book
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Emilie de Ravin
After playing Claire Littleton, de Ravin returned to ABC to reunite with Lost writers Adam Horowitz and Edward Kitsis on Once Upon a Time, where she plays Beauty and the Beast's Belle.
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Emerson, who played Ben Linus, stuck with the Bad Robot family, joining CBS' Person of Interest as mysterious billionaire Harold Finch.
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Henry Ian Cusick
Cusick, who played Desmond Hume, had roles on Law & Order: SVU and Body of Proof, as well as a series regular gig on the first season of Scandal. He departed before the second season and will next appear on the CW's new post-apocalyptic series The 100.
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After his character Charlie Pace died and left the ABC series, Monaghan had roles on Chuck, FlashForward and Childrens Hospital before hosting his own wildlife show, Wild Things with Dominic Monaghan on BBC America.
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After his character Michael Dawson left the series, Perrineau went on to appear in films 30 Days of Night: Dark Days and Zero Dark Thirty as well as TV series Sons of Anarchy, Law & Order: SVU and Wedding Band. He's currently appearing on NBC's new comedy Growing Up Fisher.
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After her days as fan-favorite Juliet Burke, Mitchell starred on the short-lived V remake and had a memorable guest-starring role on SVU. She now stars on NBC's Revolution.
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After playing Miles Straume, Leung had roles on The Good Wife, Deception, Zero Hour and Person of Interest, where he reunited with Lost co-star Michael Emerson. He'll next star in NBC's new medical drama Night Shift.
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After playing the ageless Richard Alpert, he went on to play the mayor in The Dark Knight, had a short stint on Psych and starred on the CW's Ringer. He currently stars on A&E's Bates Motel.
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After her short time on Lost as Shannon Rutherford, she went on to star in Taken and The Twilight Saga: Breaking Dawn. She also reunited with Lost co-star Jorge Garcia on Californication and had a short, but memorable, role on The Following's series premiere. She recently starred alongside Anna Paquin in the WIGS webseries Susanna and will star in an upcoming Wall Street drama pilot for CBS.
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Though his character Boone Carlyle died quickly on Lost, Somerhalder has made quite a name for himself starring on the CW's The Vampire Diaries as the undead (and sexy!) Damon Salvatore.
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After playing former cop Ana Lucia Cortez, Rodriguez returned to the Fast and Furious franchise and starred in Avatar, Battle: Los Angeles and Resident Evil: Retribution.
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After playing Alex Rousseau, Raymonde had roles on Hawaii Five-0, 90210 and in the big screen horror flick Texas Chainsaw 3D. She starred in Lifetime’s Jodi Arias film as the titular character before landing guest roles on Chicago Fire, Intelligence and The Big Bang Theory.
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After playing Penny Widmore on the ABC series, Walger went on to star on FlashForward, In Treatment and Common Law. She currently recurs on NBC's Parenthood.