X

Join or Sign In

Sign in to customize your TV listings

Continue with Facebook Continue with email

By joining TV Guide, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy.

Check out exclusive photos from the season premiere

Shaun Harrison
greys-anatomy-group1.jpg
1 of 10 Bob D'Amico/ABC

greys-anatomy-group1

Grey's Anatomy will launch its 10th season with a two-hour premiere on Thursday, Sept. 26 at 9/8c and TVGuide.com has the exclusive first look.
2 of 10 Richard Cartwright/ABC

greys-season10-5

Grey Sloan Memorial will be inundated with new patients when a giant mudslide in Seattle injures a group of first responders and citizens.
3 of 10 Richard Cartwright/ABC

But what about Jackson, who was in the bus explosion in the Season 9 finale?

4 of 10 Richard Cartwright/ABC

greys-season10-8

Jackson will have his hands full when both April and Stephanie want to take care of him — after April gave him an ultimatum.
5 of 10 Richard Cartwright/ABC

Could this be the end for Mousey, who was seen hitting her head in the new promo for Season 10?

6 of 10 Richard Cartwright/ABC

How will Owen handle a shorthanded ER in the wake of the storm?

7 of 10 Richard Cartwright/ABC

greys-season10-3

Callie and Arizona, who cheated with Dr. Boswell in the finale, will be forced to work together. In the second hour, Callie will make a bold decision regarding their relationship.
8 of 10 Richard Cartwright/ABC

Alien's Veronica Cartwright will guest-star in the premiere as a victim of the mudslide.

9 of 10 Richard Cartwright/ABC

In the second hour, the doctors will come together upon receiving devastating news.

10 of 10 Richard Cartwright/ABC

The fight to save those affected by the storm will continue throughout the two-hour premiere.