Grey's Anatomy: Where We Left Off and What's Next

Where we left off: Derek was offered his dream job at the National Institutes of Health in Washington, D.C. – but Meredith flatly told him she's not going with him. What's next: A bumpy road ahead, to say the least. Shonda Rhimes has teased that Season 11 is "the year of Meredith," and after Sandra Oh's departure last season, the title character may find herself lonelier than ever. Can Meredith handle losing her husband as well as her "person"? We're guessing she won't find the discovery of a third (!) half-sister in Dr. Pierce very comforting. "It's very earth-shattering information," Rhimes tells TVGuide.com. "It undoes everything Meredith thought to be true about her past and her childhood."